EASD: Fecal Transplant Flushes Insulin Resistance

From MedPage Today,

By Kristina Fiore, Staff Writer, MedPage Today
Published: September 22, 2010
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner

STOCKHOLM — Obese patients with a constellation of symptoms known as prediabetes improved insulin sensitivity with a fecal transplant from healthy thin donors, researchers here reported.

After six weeks, peripheral insulin sensitivity significantly improved in 18 patients who received feces from lean donors compared with those who received an autologous transplant (P<0.05), said Anne Vrieze, MD, of the Academic Medical Center in Amsterdam, and colleagues.

There was also a trend toward improvement in hepatic insulin sensitivity but it wasn’t significant, they reported at the European Association for the Study of Diabetes Meeting here.

“This confirms the potential role of gut microbiota in the disturbance of glucose and lipid metabolism in obesity,” Vrieze said during the presentation. “The challenge is to use this knowledge to develop therapies.”

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